Our Transfilm® is a non-dissolving patch system for dermal or transdermal delivery of your API.

Transfilm® – Controlled and predictable drug delivery through or into the skin

Transfilm® technology

The delivery of a drug via a transdermal route of application offers the best of oral and intravenous administration. Avoidance of the first-pass effect leads to better bioavailability and may result in fewer side effects. Consistent and controlled drug delivery can minimize or avoid periods of under- and overdosing. Transdermal patches deliver drugs over a longer period of time, thus allowing for reduced dosing frequency. A transdermal patch is administered by the patients themselves and administration is stopped by removal of the patch. Contrary to intravenous drips or infusion pumps, patient activity is not restricted. These numerous benefits lead to significantly improved patient compliance and as a consequence transdermal patches like our Transfilm® can offer a critical edge to new and established drugs in competitive markets.

A typical transdermal system is composed of an adhesive matrix sandwiched between a backing foil and a release liner. In the simplest case, the matrix consists of the active pharmaceutical ingredient (API) and one type of adhesive, with polyacrylate, silicone or polyisobutylene adhesives being the most commonly-used patch adhesives.

The release liner, which is removed before application, is usually a siliconized or fluoro-siliconized polyester film. The backing foil that stays on the patch, and forms the outer layer of the transdermal system, can be made from a wide range of materials. It can come in many colors and can also be printed on. There are two types of backing foils, those that greatly restrict vapor transmission (occlusive backing foils) and those that permit vapor transmission (non-occlusive). Both types of foils demonstrate advantages and disadvantages, ranging from wearing comfort to influence on patch performance.

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Transfilm® mode of action
Transfilm® patch sample